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    مقالةوبحث//ABSTRACT/viral sexually transmitted diseases

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    تاريخ التسجيل : 22/03/2010
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    مقالةوبحث//ABSTRACT/viral sexually transmitted diseases

    مُساهمة من طرف admin في السبت يوليو 09, 2011 3:59 pm

    1-
    Abstract

    Anti-herpes simplex
    virus (HSV) activities of oxyresveratrol in vitro and topical
    administration in cutaneous HSV-1 infection in mice were examined. The
    inhibitory concentrations for 50% plaque formation (IC50) of
    oxyresveratrol against HSV-1 clinical isolates and HSV-2 clinical
    isolates were 20.9–29.5 and 22.2–27.5 μg/ml, respectively. In topical
    administration in cutaneous HSV-1 infection in mice, 2.5%, 5%, 10% and
    20% oxyresveratrol in cream vehicle applied three times daily for 7 days
    after infection were evaluated and 10% and 20% oxyresveratrol cream
    were significantly effective in delaying the development of skin lesions
    and protection from death (P < 0.01). The concentration of
    10% oxyresveratrol in cream was significantly more effective than that
    of 30% oxyresveratrol in vaseline applied three times daily (P < 0.01). Oxyresveratrol cream at 20% was as effective as 5% ACV cream applied three times daily (P < 0.01). Both 10% and 20% oxyresveratrol cream were as effective as that of 5% ACV cream applied two times daily (P > 0.05).
    Therapeutic efficacy of oxyresveratrol in cream vehicle was
    dose-dependent and the maximum efficacy observed on day 6 after
    infection was shown at 10% oxyresveratrol in cream applied three times
    daily. The frequency of application of 10% oxyresveratrol cream at
    three, four and five times daily was as effective as that of 5% ACV
    cream applied five times daily (P > 0.05). These results
    demonstrated that topical administration of oxyresveratrol in novel
    cream vehicle reduced the concentration of oxyresveratrol to 10% and was
    suitable for cutaneous HSV infection.Keywords:


    • acyclovir, famciclovir, herpes simplex viruses, penciclovir, valacyclovir


    ABSTRACT:
    The prevalence of infection with herpes simplex virus (HSV) continues
    to increase largely due to the inability of current antiviral agents to
    eradicate latent infection. This article reviews strategies to slow the
    transmission of HSV infection, most importantly through the development
    of vaccines, as well as established and emerging choices for treatment
    of primary and recurrent genital herpes, herpes labialis, infections in
    immunocompromised hosts, and acyclovir-resistant infections. The role of
    chronic suppressive therapy in the management of genital herpes as well
    as its potential impact on transmission rates will also be discussed.
    Herpes
    simplex virus (HSV) is a widespread pathogen in the United States, with
    more than 100 million U.S. citizens having serologic evidence of HSV-1
    infection and 40–60 million, nearly one-fifth of the adolescent and
    adult population, infected with HSV-2 [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط]. The prevalence of HSV-2, the major cause of genital herpes, has increased 30% since the late 1970s [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط].
    The fact that most of those infected with HSV are asymptomatic and yet
    may still be subclinically shedding virus further complicates efforts to
    slow the spread of transmission [ندعوك للتسجيل في المنتدى أو التعريف بنفسك لمعاينة هذا الرابط].
    Therefore proper management of herpetic infections requires that the
    clinician be able to effectively diagnose those with HSV infection, to
    educate them regarding means of spread and symptoms indicative of
    infection, and to adequately treat infections which are identified in
    order to alleviate patient symptoms and slow the transmission of the
    virus. We review options for preventing infection, treating primary
    infections, and treating recurrent infections in order to accomplish
    these goals.



    3-he
    purpose of this descriptive study was to examine gender differences in
    the disease experience of persons who have genital herpes. Participants
    were 60 volunteers (34 females, 26 males) with recurrent genital herpes.
    Their average age was 31.7 years and the average length of time since
    diagnosis was 5.3 years. They completed questionnaires that included
    items about disease characteristics, disease stressors, and disease
    impact. The majority of reported stressors related to the consequences
    of the disease. A wide diversity of stressors were described, and
    results gave evidence of gender similarities in the disease experience.
    Exceptions were that women reported experiencing more worry with regard
    to negative effects on future and present health, disruption of daily
    activity, and disease symptoms. Men reported that recurrences last
    longer. Both disease symptoms and the presence of an intimate
    relationship were related to the perceived disease impact. Implications
    for sensitive interventions are discussed.

    4-ronic,
    stigmatizing, sexually transmitted disease (STD), which is increasing
    despite efforts to control its spread. Depression is commonly reported
    among people diagnosed with genital herpes and differences in depression
    by gender have been reported. Therefore, the purpose of this study was
    to identify gender differences in the predictors of depression in young
    adults with genital herpes by secondary analyses of baseline data from a
    randomized clinical trial (RCT). For the RCT, young adults (193
    females, 59 males) with genital herpes were recruited from newspaper
    advertisements. Participants completed questionnaires measuring illness
    burden, attitudes toward herpes, stress symptoms, mood states,
    depression, self-concealment, self-disclosure, substance use, and
    demographics. Univariate analyses and multiple regression techniques
    were used to identify variables predictive of depression in this sample.
    In women, increased anger, decreased vigor, increased confusion, a
    negative attitude toward herpes, self-concealment, and stress symptoms
    from genital herpes predicted more depression (R2=
    0.63). In men, increased depression was predicted by increased anger, a
    negative attitude toward herpes, and a decreased willingness to share
    personal information with a stranger (R2= 0.51).
    Findings suggest that future psychoeducational interventions should
    address anger as a predictor of depression in this population.
    Gender-specific interventions need to be developed in order to assist
    young adults who are living with genital herpes.
    6-
    Objective. To study the possible links
    between recurrent symptomatic genital herpes during pregnancy and risk
    for congenital abnormalities (CAs). Method. The occurrence of
    prospectively and medically-recorded recurrent genital herpes during
    pregnancy in the mothers of cases with different congenital
    abnormalities and in the mothers of matched controls without CAs was
    compared in the population-based large data set of the Hungarian
    Case-Control Surveillance System of Congenital Abnormalities. Results.
    Of 22,843 cases with CAs, 59 (0.26%) were born to mothers with
    recurrent symptomatic genital herpes, while of 38,151 control newborns
    without CAs, 86 (0.23%) were born to mothers with recurrent genital
    herpes during the study pregnancy (adjusted OR: 1.1, 95% CI: 0.8–1.6).
    Pregnant women with clinically recognised recurrent genital herpes in
    the first trimester of pregnancy are not linked with a higher risk for
    any CAs. Conclusion. Recurrent genital herpes during pregnancy does not associate with a higher risk of CAs.7-Clinical
    features of genital herpes, perceived causes, stress symptoms,
    treatments, and psychosocial factors in 70 young adults as compared to
    normative data for non-patient controls are described. The clinical
    features of the disease were congruent with those of other groups
    studied. Stress was viewed as the major cause of recurrence, headaches
    the major stress symptom, and acyclovir (an antiviral drug), was the
    major treatment. Statistically significant differences were found
    between scores obtained from the sample of young adults with genital
    herpes on three of four standardized psychological instruments when
    compared with normative data for non patient controls. Young adults with
    genital herpes had a lower self concept, more psychopathology, a
    greater frequency of daily hassles, and less intensity of uplifts. No
    differences were found, however, between the two groups in scores on
    depression.

    he
    purpose of this paper is to describe gender differences in risk
    behaviors—substance use and sexual behavior—in young adults with genital
    herpes. Two-hundred fifty-two young adults with genital herpes were
    recruited into the study via newspaper advertisements in a West Coast
    metropolitan area. As a part of a large randomized clinical trial,
    participants completed questionnaires measuring demographic
    characteristics and the risk behaviors of substance use and sexual
    behavior. Participants had a mean age of 27.1 years and were largely
    Caucasian, employed, college-educated, and heterosexual. Women were two
    years younger than men and had less income. Gender differences were
    found in both substance use and sexual behavior. Men were more likely to
    report current use of illicit drugs than were women. Men were also more
    likely to report a history of gonorrhea, and urethral discharge. Women
    reported initiating sex at an older age and having fewer sexual partners
    over their lifetimes than men. There were no gender differences in use
    of condoms or spermicides specifically to prevent transmission of
    genital herpes. Further study is needed of these young adults as they
    are at high risk for transmission of the disease and also for
    contracting other sexually transmitted diseases (STDs), including human
    immunodeficiency virus (HIV) infection. Sensitive interventions are
    needed with this high-risk population.

    8-
    A descriptive survey of knowledge of genital herpes
    and attitudes to testing was conducted among antenatal clinic attendees
    at the Gold Coast Hospital, Australia. The study subjects showed a good
    knowledge of genital herpes, to a level that appears sufficient for an
    informed choice regarding herpes serology testing to be made. A
    preference for testing for genital herpes was suggested. Although
    serological testing is not routinely required, the results of the study
    indicate that discussion of genital herpes should be considered in the
    antenatal clinic setting.Human
    papillomavirus and Herpes simplex virus are the most common genital
    viral infections encountered in clinical practice worldwide. We reviewed
    the literature focusing on new and experimental treatment modalities
    for both conditions, based on to the evidence-based data available. The
    modalities evaluated include topical agents such as immune response
    modifiers (imiquimod, resiquimod, and interferon), antivirals
    (penciclovir, cidofovir, and foscarnet), sinecatechins, microbiocidals
    (SPL7013 gel, and PRO 2000 gel), along with experimental
    (oligodeoxynucleotides), immunoprophylactic, and immunotherapeutic
    vaccines.

      الوقت/التاريخ الآن هو الخميس ديسمبر 14, 2017 6:25 am