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    بحث/ABESTRACT/GENITAL WARTS

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    تاريخ التسجيل : 22/03/2010
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    الموقع : O.KATTAB@YAHOO.COM

    بحث/ABESTRACT/GENITAL WARTS

    مُساهمة من طرف admin في السبت يوليو 09, 2011 4:30 pm

    1-
    ABSTRACT:  Anogenital warts and mollusca
    contagiosum are virally induced, benign skin tumors for which there is
    no single preferable therapy. Treatments include physical and chemical
    destruction, surgical removal, and biological response modifiers to
    enhance the natural immune response. The choice of therapy is an art,
    and depends upon patient preference, finances, number of lesions, and
    lesional morphology. However, the therapy of these lesions can sometimes
    be very painful and expensive, and therapy should not be worse than the
    disease.2-Keywords:


    • human papillomavirus;
    • dysplasia;
    • genital warts


    Abstract

    Cancer-associated
    human papillomavirus (HPV) types are detected in genital warts removed
    from immunosuppressed individuals more commonly than from those
    occurring in otherwise healthy individuals. The prognosis of genital
    warts containing cancer-associated HPV types is not known. Because it is
    assumed that genital warts are benign lesions, they are usually treated
    by destructive therapies without prior knowledge of histopathology. The
    aim of the present study was to determine whether genital warts from
    individuals with or without human immunodeficiency virus (HIV) contain
    high-risk HPV types or areas of dysplasia. The study design was a
    nonrandomized analysis of genital warts removed by excision biopsy from
    15 HIV-infected patients and 15 HIV-negative patients. The tissue was
    analyzed for HPV DNA by hybrid capture, and microscopic sections of each
    biopsy were examined for areas of dysplasia. Genital warts from
    HIV-infected patients contained cancer-associated (“high risk”) HPV
    types in 9 of 15 cases, including 1 that contained only a high-risk
    type. High-grade dysplastic abnormalities were present in 2 of the 15
    lesions from this group, both of which contained high-risk HPV types.
    Four genital warts removed from HIV-negative patients contained
    high-risk HPV types, but none contained dysplastic abnormalities. It is
    concluded that genital warts from HIV-infected patients often contain
    high-risk HPV types. Such lesions may exhibit dysplastic changes. The
    frequency of dysplastic changes in genital warts from HIV-infected
    patients is not known. Biopsy of genital warts may be indicated prior to
    additional therapy in HIV-infected patients, and surgical removal
    should be considered as a preferred treatment option in these patients. J. Med. Virol. 54:69–73, 1998. © 1998 Wiley-Liss,Inc.3-Keywords:


    • anogenital;
    • condyloma;
    • cervical cancer;
    • genital warts;
    • HPV;
    • human papillomavirus;
    • vaccine


    ABSTRACT

    Genital
    human papillomavirus (HPV) is a common, usually transient, dermatologic
    infection transmitted by genital contact that can cause a variety of
    anogenital diseases, including warts (condyloma), dysplasia (cervical,
    vaginal, vulvar, anal), and squamous cell carcinoma. A number of
    treatment modalities are available to treat anogenital warts, both
    patient- and provider-applied.
    Treatment
    is efficacious, but lesions can recur. Bivalent and quadrivalent
    vaccines are approved to prevent HPV infection. Both are indicated to
    prevent cervical cancer, while the quadrivalent vaccine is also approved
    to prevent vaginal/vulvar cancers as well as genital warts in males and
    females. Providers should clearly explain the natural history and
    potential sequelae of HPV disease, counsel patients on prevention
    strategies, and recommend vaccination as an effective method of
    prevention to their patients.


    4-
    t

    Background. Genital warts is a
    common sexually transmitted disease treated by a variety of medical
    specialists. Standard therapies offer symptomatic relief but cannot
    ensure lasting remission. Using the clinical literature, claims
    databases, and a panel of experienced practitioners, the relative
    efficacy, cost, and cost effectiveness of five common treatments for
    genital warts were assessed in this study.
    Methods.
    We reviewed the clinical literature for the following genital wart
    therapies: podofilox, podophyllin, trichloroacetic acid, cryotherapy,
    and laser therapy, focusing on their relative efficacy. Physicians
    experienced in treating genital warts defined standard treatment
    protocols for men and women patients with moderate wart burdens. Using
    national claims data and protocols developed by physicians, we derived
    three economic models based on provider charges, third-party payments,
    and a resource-based relative value scale, respectively.
    Results.
    The literature review demonstrated highly variable success and
    recurrence rates among treatment methods and failed to show that one
    treatment provides consistently superior efficacy. In the economic
    models, treating women generally proved more costly than treating men
    per episode of care. This was due to the need for more extensive
    follow-up visits in the treatment of women. Total costs were highest for
    cryotherapy and lowest for a patient-applied therapy that reduced the
    need for follow-up visits.
    Conclusions.
    Clinicians should consider both clinical and cost issues when choosing
    the appropriate treatment for patients with genital warts.5-
    ABSTRACT: Warts are caused by human
    papilloma viruses (HPV) and more than 80 types of HPV have been
    described. Although some HPV types in the anogenital area can lead to
    dysplasia and cancer, most HPV infections cause histologically benign
    warts. Clinically, warts produce much morbidity, mainly due to their
    resistance to most standard therapies. Although the choice of therapy
    depends partly on the location of the warts, i.e., anogenital vs.
    non-anogenital, most treatments in the past have been anti-wart but not
    antiviral. Therefore, removal of the wart was often followed by a
    recurrence in a few weeks due to sub-clinical or latent HPV infections
    surrounding the wart. Such non-antiviral therapies included a variety of
    acids, podophyllin, podophyllotoxin, chemotherapeutic agents,
    retinoids, topical sensitizers, a spectrum of surgical techniques, and
    cryotherapy. Two drugs approved for anogenital warts have antiviral and
    immunomodulatory activity, interferon and imiquimod, although imiquimod
    is much more convenient to use. While neither of these antiviral agents
    is approved for non-anogenital warts, they do appear to have efficacy in
    these warts when used as adjunctive therapy. Experimental therapies for
    warts are currently under study and include topical cidofovir and both
    prophylactic and therapeutic HPV vaccines.6-
    It
    was formerly axiomatic that all clinical types of wart were caused by
    the same virus, the morphology of a wart being conditioned only by the
    type of epidermis which this virus infected. This was the ‘unitary’
    theory, which was formulated after a series of experimental transfers of
    warts from one part of the body to another had been performed in the
    early years of this century. According to the ‘unitary’ theory, genital
    warts were a special kind of skin wart, modified in appearance by the
    thinness of the genital epithelium and by the warm moist conditions
    prevailing in the area. Sexual contact was regarded as only one of many
    ways in which the wart virus could reach the genitals. Feelings ran high
    on the natural history of genital warts, and after Barrett, Silbar
    & McGinley (1954) suggested that they should be regarded as a
    venereal disease, one outraged physician went so far as to circularise
    336 dermato-venereologists in various countries to ask whether this view
    was correct, and 94% answered‘no'. Recent advances have necessitated a
    revision of these opinions.7-
    انقر هنا لفتح الرابط
    ملخصHuman
    papillomavirus (HPV) infection of the genital tract is one of the most
    common sexually transmitted diseases (STDs), and a subset of genital
    tract HPVs are etiologically associated with cervical cancer. The
    prevalence of HPV infection is highest among adolescents and young
    adults. This study was undertaken to explore first year college
    students’ knowledge about HPVs and to determine whether there were
    gender differences in this knowledge. An anonymous survey was
    distributed to all first year students at a private university. The
    results were analyzed by gender. We found that 96.2% of males and 95.4%
    of females had heard of genital warts, although only 4.2% of males and
    11.6% of females knew that HPV caused genital warts. Although there was a
    greater awareness of genital warts than HPV in this population,
    students were uncertain about modes of transmission of both genital
    warts and HPVs, and unclear about the importance of HPV infection
    relative to other STDs. For both men and women (87% and 87.4%,
    respectively), health education classes were the major source of
    information about STDs. We conclude that health education should be
    reconceptualized to incorporate a better understanding of STDs,
    including HPV infection, by engaging adolescents and young adults in
    exploring the biological and social context of STDs, their public health
    importance, strategies for prevention, and the uncertainty of our
    scientific knowledge.

      الوقت/التاريخ الآن هو الخميس ديسمبر 14, 2017 6:24 am